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What are the side effects of Simparica?

 by ben on 03 Jun 2019 |
54 Comment(s)

We all want to protect our pets from fleas, ticks and the diseases they carry, but some treatments can come with nasty side effects.

Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks.

Like other oral treatments, Simparicaworks by entering a dog’s bloodstream immediately after ingestion. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hours—including the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials.

Simparicaworks by impacting the nervous system of invertebrates such as fleas and ticks. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. The results are fatal for fleas and ticks but safe for mammals such as your dog.

Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrhea—both symptoms related to Fido’s digestive tract, rather than his nervous system. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet.

In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. Simparica is available in different doses for dogs 2.8 pounds and over, but has not been evaluated for use in pregnant, breeding or nursing pets. Discuss Simparica chewable treats with your veterinarian when looking for a safe, effective way to arm your dog against biting parasites and the diseases they carry.


Cheryl Bell - Comment
Cheryl Bell31 May 2020Reply
Is it possible that Simparica could cause neurological issues with my dog. He was diagnosed with "Sundowners" . I have noticed that he hardly needs no meds for this neurological issue near the end of the month. I give my dogs Simparica at the beginning of each month. Just wondering?
Laura - Comment
Laura31 May 2020Reply
I say yes! My dog steadily went downhill after I gave her the first dose of simparica. After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. The cardiologist found no heart condition that would cause this. After about a week, she started to improve. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. She is only 6 and was so full of life and energy. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. I am giving her supplements to support her heart and nerves and she's a little better each day. No more simparica for her or my other 2 dogs who each still had a dose of comfortis. No simparica for them either!
Jhenelle - Comment
Jhenelle31 May 2020Reply
Hi Laura, How is you pup doing one after getting off simparica? Our dog has had 2 Seizures this month and we are going to stop using Simparica. We think that the drug is the cause of the seizures .
Katie Duffey  - Comment
Katie Duffey 31 May 2020Reply
Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. I am currently in the same situation and we are at day 16 after giving simparica. Thank you in advance
Becky - Comment
Becky31 May 2020Reply
What is a good replacement? I need to tell my vet to switch! Mine has tremors once in a while and now I know why! No more of this med!
Nadia  - Comment
Nadia 14 Jul 2020Reply
I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. Although he didn’t continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. I’m switching back to the old stuff.
Erin Hall - Comment
Erin Hall25 Jul 2020Reply
Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. No appetite, not like Charlie. He seems dehydrated. I've tried Gatorade and Ginger ale but he only drank a little. What should I do?
Denise - Comment
Denise03 Aug 2020Reply
We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. How long do the side effects last? We wont be using this medicine ever again!
Judi - Comment
Judi05 Aug 2020Reply
Gave Simparica to my dog yesterday. Today he won’t eat, is sleeping all day, and when he is up he is panting heavily. I’m done with this drug!
Toni wallet - Comment
Toni wallet10 Aug 2020Reply
I gave my precious puppy this and 12 hours later
He is having profuse diarrhea, urinating constantly and he is supper agitated
My vet did not tell me anything about the side effects
Delmy  - Comment
Delmy 10 Aug 2020Reply
Wow same thing happened to my puppy 🤮🐶😞
Camella Johnson - Comment
Camella Johnson12 Aug 2020Reply
I am sure simparica caused a fatal seizure in my boxer. She passed away soon after taking this medication. I will never use this product again!!!!! I advise all pet owners to know the side effects. My veterinarian did not warn me of these and now my precious boxer is gone!!!!!
Wendy - Comment
Wendy16 Aug 2020Reply
I feel so sad for you Camelia. Thank you for giving information on what happened to your dog. Our new vet has recommended Simperica, but I won’t be giving it to my Collie.
John - Comment
John21 Aug 2020Reply
Gave my 28lb German Spitz her monthly prescibed dose of Simparica. Not long after ingesting the chewable she began to have tremors, but not full blown seizures. Tremors continued, on and off, for 2 hours. Took her to her Vet where I was told she had another tremor. They could either keep her there for observation or I could take her home to observe her. I took her home. She's been given this dosage for over a year. First time for this adverse reaction. 5 hours after the dose she's home resting. I'll continue to watch her.
Brooke - Comment
Brooke21 Aug 2020Reply
How long did these symptoms last? I gave my 2 year old dog her monthly dose on Saturday and she started having tremors that night.
Joey - Comment
Joey22 Aug 2020Reply
gave this to my dog three different times. This time he is having seizures. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now.
Martha Davenport - Comment
Martha Davenport03 Sep 2020Reply
Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness can’t blink right eye and drooling like bell’s palsy
Tizzo  - Comment
Tizzo 03 Sep 2020Reply
This happened the same to my dog.. how si going now with your pet?
Charlene - Comment
Charlene03 Sep 2020Reply
I am up writing this 4 a.m. since our Lambchop is too restless to sleep! Never happened before. Gave Simparica yesterday and am suspect. Has odd agitated swallowing when not eating anything. He's a 1 1/2 y.o. Coton de Tulear.
Richelle - Comment
Richelle06 Sep 2020Reply
My vet prescribed my 16 week old puppy this drug because of a skin irritation. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. She is still in the vet since 3am. My vet never mentioned that puppies under 6months cannot be prescribed this medication. Still waiting to find out of she has progressed. Very dissapointed with my vet for not informing me of the risk this has on my dog.
Pat - Comment
Pat08 Sep 2020Reply
This drug has caused our dog to loose his footing and not eat. He looked like he was having spasms. Doing better now, 2 days later. No more Simparica for him.
John - Comment
John10 Sep 2020Reply
Our dog has not been given another dose. I will be speaking to vet to switch to something else. The reaction lasted less than 12 hours. She's been fine since. Doubtful our dog will be given Simparica again.
Dave - Comment
Dave18 Sep 2020Reply
we gave our dane Simperica Brown about a day or so ago and all the sudden my sweet girl is having seizures. Never had them ever and she's only 3 1/2 yrs old. Still waiting on the vet and waiting to talk to ASPCA poison control. Furious that this out there for pets. Vets at Petsmart should know better; changing vets
Kim Kelly  - Comment
Kim Kelly 27 Sep 2020Reply
My Irish setter is weak on her left side, left side of her face is drooping and she now carries her head with a tilt to the left. It has been 20 days since I gave her the prescribed dose of Simparica. The issues started within 24 hours of the dose and continue. This was the first time she was given this drug and will be the last. I feel like this drug was pushed by my vet tech and veterinarian. My dog weighs 60 pounds and was given a dose for dogs up to 88 pounds. I feel like it was a massive overdose. She falls when she runs and when going up and down stairs. She’s not the carefree setter she was prior to this medication.
Nathalie - Comment
Nathalie04 Oct 2020Reply
This is terrible. We gave our 3.5 month old Aussie pup a dose of Simparica today (vet's prescription), and I did not see the warnings about giving it to dogs under 6 months. She had what seemed like a seizure 6 hours after ingesting this product--she was lying in her crate, she peed while lying down, and she vomited, then began rocking back and forth--and now I am terrified for her (it's Saturday, nearly midnight, so tomorrow is Sunday and everything is closed). I've spoken to emergency vets and they say they are booked solid and that I need to just monitor her through the night. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. I'm just so angry that the vet prescribed this and I am mad at myself for not researching it.
alden - Comment
alden09 Oct 2020Reply
My Labradoodle had extreme diarrhea last night. My wife and I didn't understand why. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. Thankfully there have been no other side effects. Thanks all for sharing your experiences. It really helped us to put this diarrhea condition in perspective.
Melanie  - Comment
Melanie 09 Oct 2020Reply
Can I ask how long the diarrhea lasted? I gave my 6 month old pup this medication on Monday morning and he’s had diarrhea since yesterday (Tuesday) afternoon.
Johe - Comment
Johe09 Oct 2020Reply
I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. All went well until this morning. She had terrible watery diarrhea and is not interested in eating. I too would like to know how long this symptom lasted in other dogs who experienced the same issue. I notified my vet and Zoetis, the company that makes this drug. The representative for the company says the half life is 16 days. I am worried!
Renee - Comment
Renee09 Oct 2020Reply
I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. The very next day he had diarrhea, and had it for 6 days. I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. My husband said that he felt like it would just make his coat shiny. So, I gave it to him. Now, here we are one month later and I just gave him the second dose about two hours ago. I must admit that I am pretty nervous about it, but we shall see. However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. Especially, Camelia who lost her furbaby because of a seizure that was apparently brought on by this medication. I PRAY that our baby is okay with this second dose. If by chance he starts having diarrhea again...I will not be using it anymore.
Alaina - Comment
Alaina09 Oct 2020Reply
I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. They have increased and worsened over the last 3 months. I’ve spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. The vet has not been able to diagnose a cause. I even told them about the Simparica which they don’t respond to.
They put her on Phenobarbital to stop the seizures but cause her to be very wobbly and she’s been throwing up over the last two days and stopped eating today. How can I help of the manufacturer’s of Simparica responsible for causing so many dogs to experience these adverse and most likely permanent side effects.
Kristine  - Comment
Kristine 09 Oct 2020Reply
We are experiencing the same thing. How is your dog now?
Alaina Paris - Comment
Alaina Paris09 Oct 2020Reply
Kristine, unfortunately my sweet Dolly passed away on October 9th. She continued to have seizures even she was on phenobarbital. She couldn’t walk straight anymore and stopped eating. A week after I lost her I got COVID and was in the hospital for 20 days. I am continuing to recover at home and have to use an oxygen tank. Losing my Dolly devastated me and I wanted to warn others about Simparica but I got sick. The vet won’t acknowledge it was Simparica although Dolly had no problems with seizures before. It was the first time she had taken Simparica. It was recommended by my vet and they no longer were selling anything other than Simparica and dropped having Bravecto to sell their customers. They must get some kind of monetary bonus for only selling Simparica. Are their enough people to file a class action suit? And how do we get the word out to everyone?
Rachael  - Comment
Rachael 10 Oct 2020Reply
Gave my dogs simparica and they both have lost their appetite! The king cavalier bichon mix seems to be ok just not eating much if at all. The Maltese mix is lethargic and won’t jump on bed or couch. I don’t know what to do to get this out of their system?? Please advise!
Breanna Williamson - Comment
Breanna Williamson10 Oct 2020Reply
Charcoal is a detox for medication.. i
It sure how it works on dogs but maybe do some research?
Kathy Coyne - Comment
Kathy Coyne18 Oct 2020Reply
just gave my one year old dauchund her first dose of simparica My vet didnt tell me
Dave - Comment
Dave21 Oct 2020Reply
We gave our Yorkie this and she went into seizures later in the day...what if any thing can be done
Jayne - Comment
Jayne27 Oct 2020Reply
My beautiful boxer lost his appetite after just one dose of Simparica. The following day he would not even drink water.
After a vet visit, he was put on a good gastro food and probiotics and he seems to be back to his old self. In his case it was all a digestion side effect but a nasty one also with diarrhea.
Kate - Comment
Kate14 Nov 2020Reply
I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. We rushed him to the emergency vet and they put him on keppra to stop the seizures. But im 99% sure the simparica is what caused it. And im so mad that my vet didn't inform me of the side effects and im so mad I didn't research it myself.
Andrea Dansby  - Comment
Andrea Dansby 15 Nov 2020Reply
The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, I’m very worried and concerned. Anything I can do for him? Thank you
Linda Blossom - Comment
Linda Blossom15 Nov 2020Reply
Do you have a homeopathic vet in your area?
charles lews - Comment
charles lews18 Nov 2020Reply
We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. She spent 4 nights at the University of Auburn emergency room and vet clinic. I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. I am so beyond mad, what can I do to get this out of her system and better yet what can we do to get this product off the market.
Candice - Comment
Candice19 Nov 2020Reply
This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. That evening after giving it to him he has puked various times. Will not eat or drink. I've had to syringe water in his mouth. He is acting very skittish/scared like behavior, wants to just lay down. Haven't noticed any other symptoms to him besides the puking, not eating and skittish. I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. Will be talking to the vet inregards to his side effects.
Linda - Comment
Linda20 Nov 2020Reply
I have my 14 week old pup simparica (vet recommended) 2 days ago. Poor baby has had vomiting and diarrhoea ever since. She is lethargic and doesn’t want to eat. I am keeping a close eye on her and will take her to the vet if she hasn’t improved by tonight. This crap is poison! Never again are my dogs getting oral medication for fleas & ticks. This stuff should be banned.
Linda - Comment
Linda27 Nov 2020Reply
Gave my 12 year old labradoodle simpatico just before going to my son’s for T-Day dinner. Got home 4 hours later and my dog fell down three times and is now seizing ... mainly her head . Hard fast shaking and terrified eyes. She has been the healthiest, happiest dog. Seizures are going on two hours....☹️
Linda L McPherson - Comment
Linda L McPherson01 Dec 2020Reply
Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. Seizures continue and it’s Monday. Dr said either Simparica (best case scenario), GOLPP or brain tumor. Good appetite but seizures cause her to fall...Dr says: leash walks, keep kenneled or confined in small room, no playing for 7-10 days and see what happens ???? If she recovers, cause is the Simparica. Not known if there be permanent after-effects.
Karen - Comment
Karen01 Dec 2020Reply
Omg I’m feeling sick seeing all these bad comments. Is there any good outcomes from this tablet? My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures
Alleen  - Comment
Alleen 03 Dec 2020Reply
Could use of Simparica be related to increased prevalence of mast cell tumors in dogs?
Rene' - Comment
Rene'03 Dec 2020Reply
Please see my post regarding dermatitis after giving Chihuahua his first Simparica tablet...
Tian - Comment
Tian03 Dec 2020Reply
I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. I will not give it to my puppy again, but what is a safer med. for flea and ticks? Any suggestion?
Rene' - Comment
Rene'07 Dec 2020Reply
My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. I would, still boil chicken, carrots, potatoes for his meals. He developed these big sores which scab over quickly, hair falling out here and there. He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. I quit the canned sweet potatoes (he loved them) thinking it was the syrup, that I drained anyway before adding to mixture. Everything else in his environment, world has remained the same. When he lays in the sun you can see the bumps under his skin. When I bathe him the scabs fall off and I think, oh good, this problem is going away. Then they come back! I have paid about $500 - $600 to heal the little King, but it's not working. We have an appt for a skin scraping. Has anyone had a dermatitis issue as a result of Simparica? He already has canine dementia on and off. Is due for another tablet but I have been holding off. I'm at a loss...
Susan Whitworth - Comment
Susan Whitworth08 Dec 2020Reply
Gave our Bloodhound Simparico Trip on Tuesday on Thursday he got extremely thirsty and was peeing everywhere from drinking so much water. He is eating fine with no diarrhea or vomiting. He just isn’t himself. He is a 6 month old Bloodhound so they are always hyper. We have given him pedialyte. Does this sound familiar to anyone? Thank you all so much!!!!
Dixie - Comment
Dixie09 Dec 2020Reply
Gave my 14 month old 88 lb. Puppy Simparico Trio for the first time 2 days ago. Today, he wouldn't eat or drink any water. Took to vet and she said it could be the Simparico Trio. He has been on just Simparica with no problems. Simparico Trio, will not be given to my dog ever again.
Carol - Comment
Carol12 Dec 2020Reply
This may post twice - I didn't see my original post so I'm trying again! I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. We have never had issues with him peeing in the house - EVER, and he peed in my office. We had family in for the weekend and he was not himself. Not wanting to play, shivering, and drinking excessively. Once again peed in my office on Saturday. Sunday I started watching how much water he was drinking feeling bad that I was restricting him, so I made sure to take him out to pee every few hours. Getting him to go out was nearly impossible. It seemed impossible that our boy could age years in literally 3 days. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. Even when asked to go for a car ride he didn't respond. Today is Friday. He woke up and seemed much brighter. I threw him his ball and he actually was interested in it. This morning was the first morning he left water in his bowl. Hopefully, there is no permanent damage to his brain or body. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful.
Carol - Comment
Carol12 Dec 2020Reply
UPDATE We had one normal day on Friday. Saturday he started up the drinking again and threw up his breakfast. Sunday, he was lethargic and refused to eat. I finally got him to eat some chicken and he threw that up 2 hours later. Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. Refused to eat the rice and sweet potato I made for him last night.
Svetlana Borkinskaya - Comment
Svetlana Borkinskaya12 Dec 2020Reply
My aunt gave her 5.5-kg, 13-year-old female shih tzu the first dose of Simparica and she has never been the same as she shows symptoms of cardiopulmonary illness: lethargy, loss of appetite, vomit, coughing, seizure and excessive drinking. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. Now her dog is very sick and she has to take the dog to the vet every day in the past week. And it looks like the liver and/or the kidney will not take it too. If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. Don't risk the well-being of your beloved dog just because something is more convenient.
Karen - Comment
Karen12 Dec 2020Reply
I was giving my 70 lb golden doodle Trifexus, for nearly 2 years until suddenly he refused to eat it. The company that makes it said they didn’t change the flavor, but I live in a high tick area, so switched to Simparica Trio. I gave the 1st one to my dog, 1st of this month. No side effects. I suppose with any drug, during trials, there will be some who have side effects ranging from negligible to life threatening. If most side effects are mild, ( vomiting 12 hours later could be due to other things the dog has eaten within those 12 hours), I am ok with that.
I want to know, what was the size of the test group, and how many dogs had each side effect? Is there a way to find this out? And, is a 3 month trial really long enough for a drug that is basically an insecticide?
BR - Comment
BR16 Dec 2020Reply
All these comments sadden me!
My pup has had zero adverse side effects to Simparica Trio and I hope that continues.
For those asking about the trials -- I found the information here
jewels - Comment
jewels19 Dec 2020Reply
my vet recommended this for both my yorkies. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. I gave it to her then I looked at the box that said never tested on pregnant dogs . lola weighs about 9lbs. she has shaking off and on . not eating alor and wants me to rub her tummy constantly . like she wants me to fix it. I am very worried I called the vet they said oops sorry they made a mistake. so what about her puppies I am so worried.
jewels - Comment
jewels19 Dec 2020Reply
well my lola went into labor xmas day. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems.
Patti Shannon - Comment
Patti Shannon25 Dec 2020Reply
My 11 year old mini Aussie has been taking Simparica 1.5 years. Last month she had diarrhea and it lasted 7 days. Like many of you, I was unsure about the cause. But this month we are at day 7 and I expect the diarrhea it to continue. This time I am seeing a little blood or tissue in her stool. Over the past month she has stumbled a few times when on walks. Never happened before. Reading your comments, this drug may be the cause. I’m throwing away the remaining 5 pills and going back to a topical medicine. I hope this drug has not caused permanent damage.
GD - Comment
GD28 Dec 2020Reply
We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. Lost his appetite & was low on energy all day yesterday, slept most of the day - which is very unusual for him. Today started diarrhea & he has gone 5 times so far while not eating much. Plan to take him to see the vet tomorrow. Wonder why PetSmart offers this if there are so many concerns reported.

Few questions
- have you guys asked for these issues to be reported by the vet to company & FDA?
- how long does the symptoms last? A little concerned & worried about the little puppy
Susan Dowling - Comment
Susan Dowling30 Dec 2020Reply
Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. He’s very lethargic and constant vomiting! I will never give this again!
Randi - Comment
Randi06 Jan 2021Reply
Today was my 14 year old Jack Russell's 2nd dose of Simparica, her name is Rallye. After her first dose she had diarrhea, vomiting and developed a terrible wheezing hacking cough. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. It is better but not gone. Then she started having tremors. This is still going on weeks later.
Additionally she is having urination problems. She goes like 50 times a day and it is long and slow. I told the vet about her first dose and they said "oh that's a good medication" and attributed her symptoms to her age and possibly a heart condition. Tonight after her second dose she is having significant tremors and now loss of balance. I am now CONVINCED it is from this medication and she will not be taking this nor any other flea meds for the rest of her life. It's not worth it. What a shame that we only research meds after something goes wrong. We should be able to take our vets advice. Rallye will make it through this.
Connie - Comment
Connie07 Jan 2021Reply
Gave our 23 month old Black Lab. Didn’t notice anything with first dose. She has had tremors, very lethargic, drinking lots of water. Vet said they don’t think it has anything to do with the Simparica. That is the only thing that has changed in her routine. Advised I could call Simparica for reimbursement or to report side effects. Advised her to put a big note on our account that she is never to have this again. Nothing they can do for her she said. If she had just taken it they could give her Charcoal. I hate giving her these drugs in the first place but am always convinced it is the right thing to do.
Mary Kocian - Comment
Mary Kocian07 Jan 2021Reply
I will not in good conscience continue to give my three previously healthy dogs anymore Simparica Trio as it causing Gand Mal seizures in my older dog and nausea , vomiting and severe thirst and dehydration. This is lethal medication for dogs and should be taken off the market now.
Bradon - Comment
Bradon09 Jan 2021Reply
I feel so bad ,my 8weeks cockerspaniel hasn’t been the same 24 hours of giving first dose of Simparica trio.My boy has been distressed with lethargic conditions,sleepy and peeing . Although the mother that took the same had not shown any effects.
Tommy - Comment
Tommy11 Jan 2021Reply
I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. It’s Sunday night and still vomiting. I wish I could get it out of her system
Jean - Comment
Jean16 Jan 2021Reply
Our 6 year old, 66# Treeing Walker Coon Hound baby has been taking Simparica for about two years. This past October he just wasn't the same. No running or jumping, Continuously wandering around the fence line of the back yard. Head down, tail down, will stand in a corner and stare at the wall. I have to turn him around and lead him away. Not drinking any water but drooling and swallowing all the time. No problem eating. Has started to stumble and sleeps 10 to 12 hours at a time. Snores like a big dog. Eyes roll back. Very "out of it". Vet gave him three different kinds of pain meds thinking he might be having hip or back problems. He has never acted like he was in pain. No diarrhea or vomiting or seizures. Lethargic and confused. Sometimes I think he is either blind or deaf. May not be from this med but too strange to at least not think about it. Will be back at PetSmart on Monday.
Christine - Comment
Christine17 Jan 2021Reply
Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. On Jan 4th for the first time
Watson threw up and continued to a couple more times -and seems ok now but Frazier a day or so later had a gran mal seizure lasting almost 2 minutes he had another one the next morning a small
One - he has not been the same since - he has tremors has fallen down is confused and appears to be blind in one eye now and just paces over and over
He does eat and drink comes when you call him sits lays down when told and still loves his treats but does not seem to enjoy his chew bones any longer and is just not the same loving silly active boy he has always been -
We are on day 13 and I want to know has anyones pup had improvements as time went on getting this poison out of their system?
I have been giving him blueberries bananas and cognitive therapy treats - to help with clearing the toxins and such
Are there any other suggestions or methods that have worked on healing their pup successfully from this poison besides time?!
My husband is convinced that the damage is irreversible and we should let him go but I am having a hard time and trying everything I can research or think of to pull him out of it.
Like all of you I am so heartbroken over this and so angry - why is this poison even scripted to fur babies?!
Robert Cruz - Comment
Robert Cruz18 Jan 2021Reply
On 01/07/21, we gave our 11 year old black lab, Rawley, a 2nd dose of Simparico TRIO. A few hours later, he began vomiting nonstop. He could not hold down any food or water. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. After seeing his condition worsen, that night we took him to an after hours urgent care. He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. After he was sent home, he was still not well and barely able to hold in any food and had to take any fluids intravenously. A week and a half from taking the drug, he is still on 3 meds, taking fluids and starting to gain strength and eat food and drink water in very small amounts. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. Needless to say, we will no longer be giving this to our lab or our other dog. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. org to have this poison recalled. I hope these steps will prevent anyone else's pet having to endure this.
Gail Masonholder - Comment
Gail Masonholder22 Jan 2021Reply
Our 3 mo.old Boston Terrier, 10 lbs, had her first dose of Simparaco yesterday. the vet suggested it because she has hookworm..This morning she was shaking and no appetite..After reading all these comments I am scared to death for her. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure
Julie Bunce - Comment
Julie Bunce23 Jan 2021Reply
My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. I am also very worried about him. I will never give another dose to him!

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